Philippe Coutinho will be out for three months having undergone surgery on his knee.
The Barcelona star's operation was successful and he will now begin his rehabilitation process.
Coutinho has looked to force his way into Ronald Koeman's plans having been loaned out last season.
The Brazilian has started eight of their 16 La Liga games and made 14 appearances in all competitions.
Coutinho has scored three times for a Barcelona side that are considerably off the pace domestically and could finish the season trophyless.
The former Liverpool man has been linked with a Nou Camp exit but has remained in Spain for now.
A Premier League return has been touted but back in November his agent Kia Joorabchian declared their intention to stay put.
"I have heard nothing and we have no plans to move from Barca. Let's hope that Coutinho can contribute to a successful season," he said.
Koeman has been able to get more out of the player than previous managers with the 28-year-old unable to hit the heights he achieved at Liverpool.
But a positional change seems to have made the difference with the Dutchman previously discussing his improvement.
He told Sport: "He's a player that learned a lot in England, a lot in Bayern Munich. My job as a coach is to get the best out of every player.
"And that starts by putting them in their position. I think that generates more confidence.
"All that helps but it starts with the quality in the player and Coutinho's a great player."
Last term Coutinho won the treble with Bayern Munich during a loan spell.
The Germans opted against making the temporary switch a permanent one.
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