Thierry Henry remains without a win since taking charge of Monaco after they were beaten 4-0 at home by Club Brugge in Group A.
Hans Vanaken scored twice in the space of five first-half minutes to put the visitors firmly in control and Wesley made it three with a superb curling shot to put the game beyond the Ligue 1 strugglers before half-time.
Brugge skipper Ruud Vormer capped a fine display with a well-taken fourth late on.
Also in Group A, Atletico Madrid gained revenge for their 4-0 defeat to Borussia Dortmund a fortnight ago with a 2-0 victory at Wanda Metropolitano.
They opened the scoring when a pass from Filipe Luis was dummied by Angel Correa and Saul’s scuffed shot deflected in off Manuel Akanji. Antoine Griezmann held off his marker to seal the three points with 10 minutes remaining.
Group D leaders Porto were comfortable 4-1 winners at home to Lokomotiv Moscow, with Hector Herrara giving Porto the lead after two minutes.
Moussa Marega made it two with a powerful run and finish but Lokomotiv Moscow pulled one back through substitute Jefferson Farfan’s neat header.
Jesus Corona made the game safe for Porto and Monteiro Otavio added a fourth in stoppage time.
Schalke pulled clear in second place with a 2-0 win at home to Galatasaray.
Guido Burgstaller took advantage of a goalkeeping error from Fernando Muslera to curl in the opener after four minutes and Mark Uth made it 2-0 with a cool finish.
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