Eddie Jones will lead England into Six Nations battle without 10 of the squad that took them to the World Cup final.
Jones warned in November that he would change 20 to 30 per cent of the squad that fell short in Japan in order to “regenerate” it.
Missing are backs Jack Nowell, Ben Spencer, Piers Francis, Henry Slade, Ruaridh McConnochie and Joe Cokanasiga plus forwards Mark Wilson, Dan Cole, Jack Singleton and the Billy Vunipola.
A number of those absentees are injured, most notably Vunipola whom Saracens confirmed this morning had broken his forearm for a fourth time.
But axed are Nowell, Spencer, Singleton and Cole, who had a torrid time in the scrum against South Africa in England's Final defeat.
Jones said: “It is always about winning the next game so we have picked the best squad available. At the same time we wanted to bring some young players in because we need to keep building our depth so for those new players it is an exciting opportunity for them.”
Of the eight uncapped players called in, Ben Earl, Ollie Thorley and Tom Dunn have been involved in previous squads. Fraser Dingwall, George Furbank, Alex Moon, Will Stuart and Jacob Umaga are called up for the first time.
Umaga, 21, is the nephew of former New Zealad captain Tana.
Leicester-bound coach Steve Borthwick will remain with England for the duration of the Championship, the Rugby Football Union have confirmed.
Jones added: “The Guinness Six Nations for us is all about raising the standards in terms of the way we prepare, tactically and physically how we play the game, and the way we come together off the field.
“But our first task is beating France in France and that is the only game we need to worry about. We will begin our preparations in Portugal, get a bit of sun, some warm conditions and get ourselves physically and mentally right for the game.
"The first three days will be about getting organised. We have got players from 11 clubs so we need to get everyone on the same page quickly, spend a lot of time working on our togetherness and then by Tuesday next week we are in Test preparation for France.”
England fly to Portugal on Thursday ahead of their first match against France in Paris on Sunday weekForwards
Luke Cowan-Dickie (Exeter Chiefs, 21 caps)
Tom Curry (Sale Sharks, 19 caps)
Tom Dunn (Exeter Chiefs, uncapped)
Ben Earl (Saracens, uncapped)
Charlie Ewels (Bath Rugby, 12 caps)
Ellis Genge (Leicester Tigers, 14 caps)
Jamie George (Saracens, 45 caps)
Ted Hill (Worcester Warriors, 1 cap)
Maro Itoje (Saracens, 34 caps)
George Kruis (Saracens, 41 caps)
Joe Launchbury (Wasps, 62 caps)
Courtney Lawes (Northampton Saints, 81 caps)
Lewis Ludlam (Northampton Saints, 6 caps)
Joe Marler (Harlequins, 68 caps)
Alex Moon (Northampton Saints, uncapped)
Kyle Sinckler (Harlequins, 31 caps)
Will Stuart (Bath Rugby, uncapped)
Sam Underhill (Bath Rugby, 15 caps)
Mako Vunipola (Saracens, 58 caps)
Harry Williams (Exeter Chiefs, 18 caps)
Elliot Daly (Saracens, 39 caps)
Ollie Devoto (Exeter Chiefs, 1 cap)
Fraser Dingwall (Northampton Saints, uncapped)
Owen Farrell (Saracens, 79 caps)
George Ford (Leicester Tigers, 65 caps)
George Furbank (Northampton Saints, uncapped)
Willi Heinz (Gloucester Rugby, 9 caps)
Jonathan Joseph (Bath Rugby, 47 caps)
Jonny May (Leicester Tigers, 52 caps)
Ollie Thorley (Gloucester Rugby, uncapped)
Manu Tuilagi (Leicester Tigers, 40 caps)
Jacob Umaga (Wasps, uncapped)
Anthony Watson (Bath Rugby, 42 caps)
Ben Youngs (Leicester Tigers, 95 caps)
Alex Mitchell (Northampton Saints, uncapped)
Josh Hodge (Newcastle Falcons, uncapped)
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